Author

Florian Perrin

Ludwig Cancer ResearchORCID 0000-0001-9273-1772Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Céline VrancxiD· 3 shared Pascal Kienlen‐CampardiD· 3 shared Devkee M. VadukuliD· 2 shared Núria SuelvesiD· 2 shared Rémi Opsomer· 2 shared Sabrina Contino· 2 shared Anna Doshina· 1 shared Bernadette Tasiaux· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

Céline VrancxORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceMolecular NeurobiologyPeer-reviewedOct 4, 2021

Mechanism of cellular production and in vivo seeding effects of hexameric β-amyloid assemblies

Céline Vrancx, Devkee M. Vadukul, Núria Suelves…·Pascal Kienlen‐Campard

This study investigates the effects of hexameric β-amyloid assemblies on neuronal viability and amyloid deposition, finding no direct toxicity but an aggravating role in amyloid formation.

8 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceiSciencePeer-reviewedDec 1, 2020

Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization

Florian Perrin, Nicolas Papadopoulos, Núria Suelves…·Stefan N. Constantinescu

The paper shows that dimeric orientations of C99 influence γ-secretase cleavage lines, affecting Aβ42 processing and gene transcription.

20 citations

humanexperimental assay

𝕏 PostBluesky

NeuroscienceeNeuroPeer-reviewedApr 23, 2020

Amyloid Precursor Protein (APP) controls excitatory/inhibitory synaptic inputs by regulating the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4)

Rémi Opsomer, Sabrina Contino, Florian Perrin…·Pascal Kienlen‐Campard

This study identifies NPAS4 as a target of APP regulation, showing APP controls excitatory/inhibitory synaptic inputs by modulating NPAS4 expression in neurons.

34 citations

mousebulk RNA-seq

𝕏 PostBluesky