Devkee M. Vadukul

This study engineers a dimeric single-domain antibody that improves detection and neutralization of amyloid-β oligomers, showing enhanced specificity and efficacy compared to its monomeric form.

This study investigates how N-terminal truncation and surface wetting influence α-synuclein condensate maturation and suggests a mechanism linking surface interactions to toxic aggregate formation.

This paper introduces a combined SICM-OPM system for simultaneous non-contact topographical and volumetric fluorescence imaging in live cells, demonstrating its use in studying cellular remodeling and molecular delivery.

This study investigates the effects of hexameric β-amyloid assemblies on neuronal viability and amyloid deposition, finding no direct toxicity but an aggravating role in amyloid formation.

The paper shows that PS1 and PS2 deficiency in primary neurons and astrocytes does not cause mitochondrial dysfunction, contrasting with findings in immortalized cell lines.

The paper shows that dimeric orientations of C99 influence γ-secretase cleavage lines, affecting Aβ42 processing and gene transcription.

The paper uses optical reporters to show that Aβ42 oligomers disrupt the endo-lysosomal pathway by impairing protein uptake and causing lysosomal accumulation.