Author

Rémi Opsomer

UCLouvain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Pascal Kienlen‐CampardiD· 3 shared Bernadette Tasiaux· 2 shared Céline VrancxiD· 2 shared Florian PerriniD· 2 shared Jean‐Noël Octave· 2 shared Anna Doshina· 1 shared Caroline Evrard· 1 shared Devkee M. VadukuliD· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Pascal Kienlen‐CampardORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization

Florian Perrin, Nicolas Papadopoulos, Núria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen‐Campard, Stefan N. Constantinescu

The paper shows that dimeric orientations of C99 influence γ-secretase cleavage lines, affecting Aβ42 processing and gene transcription.

iScience · Dec 1, 2020Peer-reviewedNeuroscience

Amyloid Precursor Protein (APP) controls excitatory/inhibitory synaptic inputs by regulating the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4)

Rémi Opsomer, Sabrina Contino, Florian Perrin, Roberta Gualdani, Bernadette Tasiaux, Pierre J. Doyen, Maxime Vergouts, Céline Vrancx, Anna Doshina, Nathalie Pierrot, Jean‐Noël Octave, Philippe L. Gailly, Serena Stanga, Pascal Kienlen‐Campard

This study identifies NPAS4 as a target of APP regulation, showing APP controls excitatory/inhibitory synaptic inputs by modulating NPAS4 expression in neurons.

eNeuro · Apr 23, 2020Peer-reviewedNeuroscience

Contribution of the endosomal-lysosomal and proteasomal systems in Amyloid-β Precursor Protein derived fragments processing

Caroline Evrard, Pascal Kienlen‐Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean‐Noël Octave, Luc Buée, Nicolas Sergeant, Valérie Vingtdeux

This study investigates the roles of endosomal-lysosomal and proteasomal pathways in processing APP-derived fragments, showing distinct degradation mechanisms for full-length APP and overexpressed C99.

Frontiers in Cellular Neuroscience · Nov 22, 2018Peer-reviewedNeuroscience