Peripheral opioid tolerance involves skin keratinocytes and platelet-derived growth factor type B signaling
Luca Posa, Sophia A. Miracle, Kathryn M. Albers…·Stéphanie Puig
This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.