Kathryn M. Albers

This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.

This study inhibits the colon epithelium and primary afferent neurons in a mouse model of IBD to assess their role in pain hypersensitivity, finding both reduce visceral sensitivity.

The paper uses molecular profiling to show that visceral afferents from different ganglia have distinct gene expression patterns, indicating functional specialization and integration of sensory information.

The paper uses single cell qPCR and functional assays to correlate gene expression with functional properties in identified sensory neurons, finding transcriptional heterogeneity within functional subgroups.