Luca Posa

This paper introduces a photoswitchable opioid agonist that enables optical control of peripheral analgesia with reduced side effects.

This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.

The paper investigates the role of serotonin in pain modulation, finding that sustained serotonin signaling in the spinal trigeminal nucleus is pronociceptive in chronic pain models.

This study shows that norepinephrine transients in the parabrachial nucleus, induced by cNTScat input, amplify PB activity and sensory afferent responses in mice.