Stéphanie Puig

The paper develops a computational method to prioritize neuroactive ligands using structural data and zebrafish testing, identifying effective antagonists for hypocretin receptors.

This study maps morphine-induced brain activity in male and female mice over time, revealing sex-specific and time-dependent patterns of c-Fos expression.

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.

This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.

The paper characterizes striatal projection neuron heterogeneity in mice using single-nuclei multi-omics and spatial mapping, revealing distinct subtypes with unique receptor expression and disease risk contributions.

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

This study investigates the sex-specific role of NPAS2 in fentanyl-induced analgesia, tolerance, hyperalgesia, and dependence using NPAS2-deficient mice.

This study examines how fentanyl affects sleep architecture and how the circadian factor NPAS2 influences these changes during withdrawal in male mice.

The paper finds a lateralized decrease in parvalbumin+ basket cells in the dominant hemisphere of ASD mouse models, correlated with tactile hypersensitivity in the dominant hind paw.