Matthew V. Chafee

NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration

This study shows that NMDA receptor loss in the medial prefrontal cortex impairs value updating and reward history integration in mice, mimicking schizophrenia-like cognitive deficits.

Monkey Prefrontal Cortex Learns to Minimize Sequence Prediction Error

This study introduces a novel RNN model called SPEL that mimics prefrontal cortex activity by minimizing sequence prediction error, showing it matches neural responses and behavior in monkeys.

A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

This paper develops a prefrontal network model to show how NMDAR synaptic deficits in schizophrenia disrupt spike timing and prevent network state transitions.