Author

Ruban Rex Peter Durairaj

UK Dementia Research InstituteORCID 0000-0001-9289-6569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:variant calling· 3 Approach:experimental assay· 2 Assay:long-read sequencing· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alys N AstoniD· 3 shared Emma L. RandalliD· 3 shared Laura HeratyiD· 3 shared Vincent DioniD· 3 shared Aeverie E. R. HeuchaniD· 2 shared Alvaro MurilloiD· 2 shared Alysha S TayloriD· 2 shared Christopher SmithiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Alys N AstonORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 8, 2026

✦ In-depth digest

A novel analysis pipeline and experimental design for measuring expanded repeat instability

Christopher Smith, Ruban Rex Peter Durairaj, Emma L. Randall…·Vincent Dion

Delta plots from targeted long-read data separate repeat instability frequency, expansion bias and change size; a single-clone assay (SCIA) shows FAN1 knockout raises expansion frequency but shrinks expansions.

1 citation

humanmouse

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BioinformaticsbioRxivPreprintJul 26, 2026

Targeted sequencing of expanded tandem repeats: Identifying interruptions and errors

Aeverie E. R. Heuchan, Ruban Rex Peter Durairaj, Alys N Aston…·Vincent Dion

The paper develops CHARLIE, a method to identify interruptions and errors in expanded tandem repeats using targeted sequencing, validated on Huntington's disease and myotonic dystrophy type 1 samples.

DOI 10.64898/2026.07.23.739298

humanlong-read sequencing

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NeurosciencebioRxivPreprintFeb 19, 2024

Cas9 Nickase-Mediated Contraction of CAG/CTG Repeats in Vivo is Accompanied by Improvements in Huntington's Disease Pathology

Alvaro Murillo, Melanie Alpaugh, Ruban Rex Peter Durairaj…·Vincent Dion

The paper demonstrates that CRISPR-Cas9 nickase can contract CAG/CTG repeats in patient-derived cells and improve molecular and behavioral phenotypes in Huntington's disease.

8 citations

humanmouse

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