Aaron D. Silva Trenkle

Multimodal epi-mode 3D quantitative phase and fluorescence microscopy enables supervised volumetric virtual fluorescence in bulk tissue

This paper introduces a multimodal microscope that uses a cGAN to generate virtual fluorescence images from phase contrast data, enabling virtual histological staining of bulk tissues.

Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1

This paper develops a high-throughput method to identify and characterize neutralizing antibodies in vaccinated rhesus macaques, revealing key features of effective antibody responses.

Label- and slide-free multispectral quantitative epi-illumination deep-UV microscopy

This paper introduces a label- and slide-free deep-UV microscope for imaging fresh thick tissues, providing quantitative molecular maps and H&E-like contrast without chemical processing.

Label-Free In-Line Characterization of Immune Cell Culture using Quantitative Phase Imaging

This paper introduces qOBM for non-destructive, label-free monitoring of T cell cultures, showing strong correlation with traditional assays and potential for improving cell therapy development.

Non-destructive, high-resolution T cell characterization and subtyping via deep-ultraviolet microscopy

This paper introduces deep-ultraviolet microscopy for non-destructive T cell characterization and subtyping, showing high accuracy in viability, activation state, and subtype classification.