Amanda Metz

This paper develops a high-throughput method to identify and characterize neutralizing antibodies in vaccinated rhesus macaques, revealing key features of effective antibody responses.

The paper investigates how vaccine antigen delivery and adjuvant selection affect the priming of rare HIV broadly neutralizing antibody-precursor B cells in non-human primates, finding that specific dosing and adjuvant combinations enhance their detection in germinal centers.

The paper develops methodologies to generate and analyze immunoglobulin loci variation in rhesus macaques, revealing extensive diversity and expanding existing allele sets by 60%.

The paper shows that eosinophils protect against SARS-CoV-2 in vaccinated mice during breakthrough infections by reducing viral burden and limiting dissemination.

The paper uses scRNA-seq to analyze the antiviral response in human dendritic cells infected with ZIKV, identifying a network of host genes and proteins involved in antiviral defense.