Greg Joyner

This study evaluates the protective efficacy of modified OspA vaccines delivered via different vehicles and routes, finding no significant difference in effectiveness against Borrelia burgdorferi.

A field trial tested an OspA-based oral vaccine targeting reservoir mice, showing reduced tick infection rates and increased antibody levels in vaccinated mice.

This study shows that maternal transfer of anti-OspA antibodies from vaccinated Peromyscus leucopus dams protects pups from tick-transmitted Borrelia burgdorferi infection.