Maria J. C. Gomes-Solecki

Modified OspA Delivered Via Distinct Vehicles and Routes Confers Equivalent Protection Against Tick-Transmitted Borrelia burgdorferi

This study evaluates the protective efficacy of modified OspA vaccines delivered via different vehicles and routes, finding no significant difference in effectiveness against Borrelia burgdorferi.

A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against Borrelia burgdorferi

A field trial tested an OspA-based oral vaccine targeting reservoir mice, showing reduced tick infection rates and increased antibody levels in vaccinated mice.

Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic Leptospira interrogans Infection

Maternal Transfer of Oral Vaccine Induced Anti-OspA Antibodies Protects Peromyscus spp Pups from Tick-Transmitted Borrelia burgdorferi

This study shows that maternal transfer of anti-OspA antibodies from vaccinated Peromyscus leucopus dams protects pups from tick-transmitted Borrelia burgdorferi infection.

TLR4 competence and mouse models of leptospirosis

This study compares TLR4-competent and hyporesponsive mouse strains to determine their susceptibility to leptospirosis, finding that TLR4 function is important but not sufficient for disease susceptibility.

Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

This study shows that prior exposure to saprophytic Leptospira reduces severe leptospirosis symptoms and kidney fibrosis when mice are later infected with a pathogenic serovar.

Transdermal, but not oral mucosa exposure, causes sublethal leptospirosis in mice

This study compares transdermal and oral mucosa infection routes in mice to determine how they affect Leptospira dissemination and disease progression.

Lethality of leptospirosis depends on sex: male hamsters succumb to infection with lower doses of pathogenic Leptospira

This study shows male hamsters are more susceptible to leptospirosis than females, succumbing to lower infectious doses of L. interrogans.

Diagnosis of Human Leptospirosis: High Resolution Melting Analysis for Direct Detection of Leptospira in the Early Stage of the Disease in a Clinical Setting

The paper compares high resolution melting analysis with nested PCR and MAT for diagnosing leptospirosis, finding HRM detects Leptospira earlier than serologic tests.