Suman Kundu

This study evaluates the protective efficacy of modified OspA vaccines delivered via different vehicles and routes, finding no significant difference in effectiveness against Borrelia burgdorferi.

A field trial tested an OspA-based oral vaccine targeting reservoir mice, showing reduced tick infection rates and increased antibody levels in vaccinated mice.

This study shows that maternal transfer of anti-OspA antibodies from vaccinated Peromyscus leucopus dams protects pups from tick-transmitted Borrelia burgdorferi infection.

This study compares TLR4-competent and hyporesponsive mouse strains to determine their susceptibility to leptospirosis, finding that TLR4 function is important but not sufficient for disease susceptibility.

This study shows that prior exposure to saprophytic Leptospira reduces severe leptospirosis symptoms and kidney fibrosis when mice are later infected with a pathogenic serovar.