Author

Gerald Höefler

Medical University of GrazORCID 0000-0002-9056-3063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Andreas ReinischiD· 3 shared Akshaya Kailasnathan· 2 shared Annkristin HeineiD· 2 shared Armin ZebischiD· 2 shared Bianca PerfleriD· 2 shared Dagmar KolbiD· 2 shared Eva Gruden· 2 shared Gudrun PregartneriD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMolecular Biology

Andreas ReinischORCID

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Author profile →

5 papers

Recent·Most cited

EZH2 inactivation drives MAPK-dependent vulnerability to MEK inhibition in RAS-mutant CMML

Eva Gruden, Bianca Perfler, Akshaya Kailasnathan, Panagiota Chaida, KARIN LIND, Marie-Christina Mayer, Johannes Foßelteder, Melanie Kienzl, Sayantanee Dutta, Sonja Wurm, Jennifer Neiss, Katarina Vizar Cisarova, Gerald Höefler, Karl Kashofer, Klaus Geissler, , Armin Zebisch

This study identifies RASmutEZH2inact as a distinct CMML subgroup with increased MEK inhibitor sensitivity due to MAPK/ERK hyperactivation.

bioRxiv · Jun 4, 2026 · PreprintMolecular Biology

Self-organized hemanoids derived from human iPSCs create a niche that produces definitive extraembryonic hematopoiesis.

Afrim Avdili, Martina Auer, Dagmar Brislinger, Dagmar Kolb, Gerit Moser, Andreas Reinisch, Gerald Höefler, Claudia Bernecker, Julia Fuchs, Julia Feichtinger, Peter Schlenke, Isabel Dorn

The paper describes a method using self-organized hemanoids from human iPSCs to generate RBCs, showing they mimic extraembryonic hematopoiesis.

bioRxiv · May 8, 2026 · PreprintDevelopmental Biology

RAS-mutant clones drive extramedullary acute myeloid leukemia

Panagiota Chaida, Julia Frimmel, Lara Hopfer, Bianca Perfler, Eva Gruden, Akshaya Kailasnathan, KARIN LIND, Bernadette Bramreiter, Johannes Foßelteder, Sonja Wurm, Jennifer Neiss, Stefan Koeck, Dominik Georg Friedrich Wolf, Gudrun Ratzinger, Nassim Ghaffari‐Tabrizi‐Wizsy, , Armin Zebisch

This study identifies RAS mutations as a key driver of extramedullary acute myeloid leukemia, showing their role in promoting leukemic cell migration and infiltration through the JAML-PI3K/AKT pathway.

bioRxiv · Apr 9, 2026 · PreprintCancer Biology

Tissue architecture and immune niches govern ctDNA release in colorectal cancer

Stefan Kühberger, Katja Sallinger, Christin-Therese Müller, Maria Escriva Conde, Sergio Marco Salas, Silvia Andaloro, Christine Beichler, Ricarda Graf, Karin Pankratz, Julia Enzi, Sarah Binder, Martina Scheiber, Lilli Bonstingl, Jasmin Blatterer, Stefan Uranitsch, , Ellen Heitzer

This study identifies tissue architecture and immune niches as key factors influencing ctDNA release in colorectal cancer by integrating spatial transcriptomics and in situ mutation detection.

bioRxiv · Nov 28, 2025 · PreprintCancer Biology

White adipose tissue browning preserves UCP1-dependent nonshivering thermogenesis upon brown-adipocyte specific lipase-deficiency

Yelina Manandhar, Anita Pirchheim, Peter Hofer, Wolfgang Krispel, Nemanja Vujić, Dagmar Kolb, Martina Schweiger, Ulrike Taschler, Robert Zimmermann, Gerald Höefler, Dagmar Kratky, Rudolf Zechner, Renate Schreiber

The paper shows that browning of white adipose tissue maintains UCP1-dependent thermogenesis despite loss of lipases in brown adipocytes.

bioRxiv · Dec 4, 2024 · PreprintPhysiology