Author

Johanna Lotila

Tampere UniversityORCID 0000-0001-9352-4150Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Henna JänttiiD· 2 shared Iisa TujulaiD· 2 shared Sanna HagmaniD· 2 shared Susanna NarkilahtiiD· 2 shared Tanja HyvärineniD· 2 shared Tarja MalmiD· 2 shared Anna HerlandiD· 1 shared Dimitrios VoulgarisiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Henna JänttiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

Tanja Hyvärinen, Johanna Lotila, Luca Giudice, Iisa Tujula, Marjo Nylund, Sohvi Ohtonen, Flavia Scoyni, Henna Jäntti, Lassi Virtanen, Sara Pihlava, Roosa Kattelus, Heli Skottman, Susanna Narkilahti, Laura M. Airas, Tarja Malm, Sanna Hagman

This study shows that microglia from MS patients have intrinsic activation features, identified through iPSC-derived microglia-like cells and transcriptomic analysis.

Journal of Neuroinflammation · Oct 31, 2025Peer-reviewedNeuroscience

Human iPSC-based coculture model reveals neuroinflammatory crosstalk between microglia and astrocytes

Iisa Tujula, Tanja Hyvärinen, Johanna Lotila, Julia Rogal, Dimitrios Voulgaris, Lassi Sukki, Kaisa Tornberg, Katri Korpela, Henna Jäntti, Tarja Malm, Anna Herland, Pasi J. Kallio, Susanna Narkilahti, Sanna Hagman

This study uses a microfluidic coculture platform to investigate inflammatory crosstalk between microglia and astrocytes, revealing altered inflammatory mediator levels and microglial migration.

bioRxiv · Jan 3, 2025 · PreprintNeuroscience