Henna Jäntti

The paper develops a method to generate functional induced astrocytes (iAstrocytes) from human pluripotent stem cells and shows their role in promoting synchronized neuronal network activity.

This study shows that microglia from MS patients have intrinsic activation features, identified through iPSC-derived microglia-like cells and transcriptomic analysis.

This study uses spatial transcriptomics and single-nucleus RNA-seq to analyze remyelination dynamics, identifying an interferon-responsive glial state that coordinates immune infiltration and oligodendrocyte differentiation.

This study uses a microfluidic coculture platform to investigate inflammatory crosstalk between microglia and astrocytes, revealing altered inflammatory mediator levels and microglial migration.

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

This study shows that C9orf72 repeat expansion in iPSC-derived microglia from FTD patients leads to increased phagocytic activity and reduced autophagosomal-lysosomal vesicles.

The paper investigates the role of CSMD1 in opposing the complement cascade in neural tissues and links its dysfunction to schizophrenia risk.