Luca Giudice

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

This study shows that microglia from MS patients have intrinsic activation features, identified through iPSC-derived microglia-like cells and transcriptomic analysis.

This study examines how early Alzheimer's disease-related pathology affects synaptic transmission and morphology in human cortical neurons using biopsies from patients with idiopathic normal pressure hydrocephalus.

The paper shows that ciRS-7 and miR-7 regulate ischemia-induced neuronal death through glutamatergic signaling in mice.

Esearch3D predicts active enhancers by propagating gene expression across 3D-genome networks, showing enrichment in enhancer-associated features.

This study shows that activating PIEZO1 channels in microglia improves amyloid beta clearance in AD models by enhancing survival, phagocytosis, and lysosomal activity.

Simpati is a patient classifier that identifies disease-related pathways using similarity networks, outperforming existing methods on cancer datasets with improved interpretability and computational efficiency.