Tarja Malm

Multidimensional diffusion MRI reveals heterogeneous microstructural remodeling associated with amyloid pathology

This study uses multidimensional diffusion MRI to show increased microstructural heterogeneity in 5xFAD mouse brains compared to wild-type, associated with amyloid pathology but not widespread degeneration.

Mechanical Activation of Piezo1 by Virus-like Nanospikes to Potentiate STING-driven Macrophage Reprogramming

This study shows virus-like nanospikes activate Piezo1 to enhance STING signaling in macrophages, promoting M1 polarization through mechanical and inflammatory signals.

Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-beta clearance in Alzheimer's disease models

This study shows diesel exhaust particles impair microglial function and amyloid-beta clearance in both mouse and human models, potentially contributing to Alzheimer's disease progression.

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

This study shows neuronal hyperactivity triggers C1q deposition on synapses, leading to synapse loss, and identifies immunoglobulins as involved in this process.

Microelectrode array scaled for recording human hippocampal slices

The paper develops a custom microelectrode array for recording extracellular action potentials and local field potentials from human hippocampal slices to study temporal lobe epilepsy.

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab

The paper develops a protocol to characterize epileptogenic tissue using multimodal data from surgical samples, aiming to improve diagnosis and treatment of drug-resistant epilepsy.

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

This study shows that microglia from MS patients have intrinsic activation features, identified through iPSC-derived microglia-like cells and transcriptomic analysis.

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

This study shows that iPSC-derived neurons from FTD patients exhibit synaptic dysfunction, DNA damage, and C9-HRE-related pathologies, supporting synaptic dysfunction as a key factor in FTD.

Ex vivo massively multidimensional diffusion-relaxation correlation MRI: scan-rescan reproducibility and caveats

This study evaluates the reproducibility of MMD-MRI metrics in ex vivo mouse brains and identifies fixation time effects.

Molecular determinants of protein pathogenicity at the single-aggregate level

This study investigates how variations in protein aggregate size, composition, and mutations affect biological functions in Alzheimer's and Parkinson's diseases.

Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer's Disease-related pathology

This study examines how early Alzheimer's disease-related pathology affects synaptic transmission and morphology in human cortical neurons using biopsies from patients with idiopathic normal pressure hydrocephalus.

Human iPSC-based coculture model reveals neuroinflammatory crosstalk between microglia and astrocytes

This study uses a microfluidic coculture platform to investigate inflammatory crosstalk between microglia and astrocytes, revealing altered inflammatory mediator levels and microglial migration.

SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

This study shows that SARS-CoV-2 and HSV-1 induce amyloid aggregation of proteins in human CSF, leading to soluble protein depletion, suggesting a potential mechanism linking viral infections to neurodegenerative diseases.

Protective variant in PLCgamma2 mitigates Alzheimer's disease associated pathology via enhancing beneficial microglia functions

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

C9orf72 repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesicles

This study shows that C9orf72 repeat expansion in iPSC-derived microglia from FTD patients leads to increased phagocytic activity and reduced autophagosomal-lysosomal vesicles.

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

The paper shows that apoE isoforms modulate Aβ aggregation, clearance, and toxicity in Alzheimer's disease, with implications for therapeutic strategies.

The critical role of isomiRs in accurate differential expression analysis of miRNA-seq data

The paper evaluates isomiR expression differences across conditions and shows their impact on miRNA-seq quantification, highlighting the need for isomiR-aware analysis.

ciRS-7 and miR7 regulate ischemia induced neuronal death via glutamatergic signaling

The paper shows that ciRS-7 and miR-7 regulate ischemia-induced neuronal death through glutamatergic signaling in mice.

Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microglia

This paper develops a method to culture midbrain organoids with microglia and air-liquid interface to improve neuronal functionality and integration of microglia.

Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states

The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.

Microglial amyloid beta clearance is driven by PIEZO1 channels

This study shows that activating PIEZO1 channels in microglia improves amyloid beta clearance in AD models by enhancing survival, phagocytosis, and lysosomal activity.

Subacute Inhalation of Ultrafine Particulate Matter Triggers Inflammation Without Altering Amyloid Beta Load in 5xFAD mice.

isomiRs-specific differential expression is the rule, not the exception: Are we missing hundreds of species in microRNA analysis?

The paper shows isomiRs significantly affect differential expression analysis and highlights the need to consider them instead of relying solely on reference miRNA sequences.

Alzheimer's disease alters astrocytic functions related to neuronal support andtranscellular internalization of mitochondria

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

Microglia orchestrate neuronal activity in brain organoids

This study shows that incorporating microglial progenitors into human brain organoids supports neuronal maturation and synaptic activity.

Disease specific alterations in the olfactory mucosa of patients with Alzheimer's disease

This study identifies disease-specific gene expression and protein secretion patterns in olfactory mucosa cells from Alzheimer's patients, revealing potential diagnostic and mechanistic insights.

The role of the meningeal lymphatic system in local inflammation and trigeminal nociception implicated in migraine pain

This study investigates the role of the meningeal lymphatic system in migraine pain by analyzing inflammatory and nociceptive responses in mice lacking this system.