Jisu Shin

This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.

This paper introduces a method to estimate cross-ancestry genetic correlation using individual-level data, finding significant genetic heterogeneity in obesity between African and European ancestry groups.

The paper identifies genetic-by-environment interactions affecting diabetes-related metabolic traits using UK Biobank data, showing lifestyle impacts vary by genetic background.

GxEsum estimates phenotypic variance from genome-wide GxE interactions using GWAS summary statistics, showing efficiency and accuracy on biobank-scale data.