Elina Hyppönen

This study uses Mendelian randomisation and colocalisation to show CD40 protein levels are not causally linked to depression, but SLC12A5 at the CD40 locus may contribute to depression risk through brain-expressed potassium chloride co-transporter effects.

This study identifies genetic factors underlying personality meta-traits stability and plasticity and their links to psychopathology using GWAS and structural equation modeling.

The paper identifies genetic markers linked to clozapine-induced metabolic dysfunction using Mendelian randomization and colocalization analyses, suggesting potential biomarkers for precision medicine.

This study examines cross-ancestry genetic architecture of cholesterol traits, finding significant genetic heterogeneity and identifying concordant SNPs with higher predictive ability.

This study introduces a novel GxE PRS model that improves type 1 error control and statistical power for genetic risk prediction, with applications to quantitative and binary traits.

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

The paper identifies genetic-by-environment interactions affecting diabetes-related metabolic traits using UK Biobank data, showing lifestyle impacts vary by genetic background.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

This study uses a whole-genome approach to identify genetic and non-genetic variance components in cardiovascular risk influenced by lifestyle factors, showing their modulating effects and implications for CVD prevention.

This paper introduces a multivariate reaction norm model to estimate genotype-covariate correlation and interaction in complex trait analyses, showing improved performance over existing methods.

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.