Author

Tae‐In Kam

Johns Hopkins UniversityORCID 0000-0002-7241-4902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:zebrafish· 1

Frequent Co-Authors

Ted M. DawsoniD· 5 shared Valina Lynn DawsoniD· 5 shared Hyejin ParkiD· 3 shared Devanik BiswasiD· 2 shared Shih-Ching Chou· 2 shared Aanishaa JhaldiyaliD· 1 shared Abhay Monghekar· 1 shared Abhishek Pasupuleti· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersNeuroscience

Ted M. DawsonORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Splanchnic-spinal transmission of gut-initiated α-synucleinopathy

Byung-Kwon Jung, Min Kyung Song, Yeongseo Kim, Dae Ki Hong, Myounghun You, Eun Hee Ahn, Seong Su Kang, Tae‐In Kam, Hyejin Park, Yoon‐Seong Kim, Greg S. B. Suh

This study shows that gut-initiated α-synucleinopathy spreads via the splanchnic-spinal pathway, not just the vagus nerve, and identifies spinal pathology in human Parkinson's disease.

bioRxiv · Oct 23, 2026 · PreprintNeuroscience

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration

Jae‐Jin Song, Hyejin Park, YuRee Choi, Taekyung Ryu, Jisu Shin, Seo-Hyun Kim, Albert Park, Justin Wang, Devanik Biswas, Shih-Ching Chou, Shinwon Ha, Yura Jang, Yu Jung Shin, Hao Wen Chen, Ingie Hong, , Tae‐In Kam

This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.

bioRxiv · Mar 4, 2026 · PreprintNeuroscience

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer Disease Model

Aanishaa Jhaldiyal, Manisha Kumari, Trupti Tripathi, Rizwan Hasan Khan, Justin L. Wang, Lauren C. Guttman, Devanik Biswas, Abhishek Pasupuleti, Akansha Aggarwal, Shraddha Pandya, Shih-Ching Chou, Nikhil Panicker, Abhay Monghekar, Marilyn Albert, Lynn M. Bekris, , Valina Lynn Dawson

This study shows PARP1 inhibition reduces amyloid pathology, neurodegeneration, and cognitive decline in a mouse model of Alzheimer's disease.

bioRxiv · Sep 6, 2025 · PreprintNeuroscience

Poly ADP-Ribose Signaling is Dysregulated in Huntington Disease Patients

Tamara Maiuri, Carlos Barba Bazan, Rachel Harding, Nola Begeja, Tae‐In Kam, Lauren M. Byrne, Filipe Brogueira Rodrigues, Monica M Warner, Kaitlyn Neuman, Muqtasid Mansoor, Mohsen Badiee, Morgan Dasovich, Keona Q. Wang, Leslie Michels Thompson, Anthony K. L. Leung, , Ray Truant

The paper identifies a deficient PAR response in Huntington disease patients, suggesting a potential therapeutic target for early intervention.

Proceedings of the National Academy of Sciences · Sep 27, 2024Peer-reviewedNeuroscience

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

Liyun Zhang, Conan Y. Chen, Jie Fu, Brendan N. Lilley, Cynthia A. Berlinicke, Baranda S. Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy S. Mulligan, Kevin Emmerich, Meera T. Saxena, Kelsi R. Hall, , Jeff S. Mumm

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

eLife · Jun 29, 2021Peer-reviewedNeuroscience

Complement and coagulation cascades are potentially involved in dopaminergic neurodegeneration in alpha-synuclein-based mouse models of Parkinson's disease

Shi-Xun Ma, Bo Am Seo, Donghoon Kim, Yulan Xiong, Seung‐Hwan Kwon, Saurav Brahmachari, Sangjune Kim, Tae‐In Kam, Raja Sekhar Nirujogi, Sang Ho Kwon, Valina Lynn Dawson, Ted M. Dawson, Akhilesh Pandey, Chan Hyun Na, Han Seok Ko

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.

Journal of Proteome Research · Jun 1, 2021Peer-reviewedNeuroscience