Kenneth A. Pelkey

This study shows that early-life disruption of the medial pulvinar in marmosets leads to adult prefrontal inhibitory and cognitive deficits relevant to schizophrenia.

This study shows that reducing H3K4 methylation in specific brain regions causes neurodevelopmental disorder-like phenotypes, including seizures, growth issues, and behavioral deficits.

This study investigates how opioid receptors modulate glutamatergic and cholinergic neurotransmission in the medial habenula/interpeduncular nucleus circuit, revealing complex developmental regulation and interactions with potassium channels.

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

The paper identifies a novel inhibitory interneuron subtype in the dentate gyrus that selectively regulates mossy cell function and shows this pattern is evolutionarily conserved across species.

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

The paper identifies and validates an enhancer-AAV for selectively targeting dentate granule cells in the hippocampus using RNAseq data.

This study shows that loss of Grin2a causes delayed electrophysiological maturation of hippocampal parvalbumin interneurons, leading to transient seizure susceptibility in mice.

This study identifies Grin1 as a key regulator of subtype-specific gene expression in MGE-derived interneurons, linking NMDAR signaling to neurodevelopmental disorders like schizophrenia.

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

The paper shows that neurogliaform cells in mouse and human exhibit similar activity-dependent changes in intrinsic excitability, suggesting conserved circuit mechanisms across species.