Evaluating the performance of polygenic indices of neuropsychiatric conditions and brain endophenotypes in four UK population samples
Anna Dearman, Pascal Vrtička, Jamie C. Moore, Meena Kumari B, Leonard C. Schalkwyk
The paper evaluates polygenic indices for neuropsychiatric conditions and brain endophenotypes across UK samples, finding environmental mediation in NPGIs and limited power in EPGIs.
medRxiv · Jul 10, 2026 · PreprintGenetic & Genomic Medicine