Brian Fulton‐Howard

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts

This paper evaluates cross-ancestry polygenic risk scores (PRS) for Alzheimer's disease across multi-ethnic populations, finding improved predictive accuracy in non-European groups.

The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes

This paper constructs a genomic-informed dementia risk score combining genetic and clinical factors and finds that most memory clinic patients have at least one high-risk indicator, with higher burden linked to increased dementia risk.

Genome-wide Association Study of Long COVID

This study performs a genome-wide association study for Long COVID, identifying a significant association with the FOXP4 locus and highlighting the role of pulmonary dysfunction and COVID-19 severity.

Genome-wide association study and functional validation implicates JADE1 in tauopathy

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants

The paper develops a method to impute missing mitochondrial DNA variants using a large reference alignment, improving haplogroup assignment and enabling better integration of mtDNA data from different sources.

Genome-Wide Meta-Analysis of Late-Onset Alzheimer's Disease Using Rare Variant Imputation in 324,809 Subjects Identifies Novel Rare Variant Locus NCK2: The International Genomics of Alzheimer's Project (IGAP)

Greater Effect of Polygenic Risk Score for Alzheimer's Disease Among Younger Cases Who are Apolipoprotein E-ϵ4 Carriers

The paper examines how polygenic risk scores for Alzheimer's disease affect younger APOE4 carriers, finding earlier disease onset associated with higher PRS.

Causal associations between potentially modifiable risk factors and the Alzheimer's phenome: A Mendelian randomization study

This study uses Mendelian randomization to assess causal relationships between 22 risk factors and the Alzheimer's phenome, finding education, blood pressure, cholesterol, smoking, and BMI have causal effects.

Mitonuclear interactions influence Alzheimer’s disease risk

The paper investigates how mitochondrial DNA haplogroups and a polygenic risk score interact to influence dementia risk and age of onset.