Geoffrey John Lindeman

This paper integrates tumor homologous recombination deficiency status with germline BRCA1 and BRCA2 variant classification to improve pathogenicity prediction.

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

The paper provides R code and processed data objects to reproduce analyses of a scRNA-seq atlas of human breast tissue across normal, preneoplastic, and tumorigenic states.