Cecilie Amalie Brøgger Svane

This study compares the response of stem-cell-derived islets to pro-inflammatory cytokines with primary human islets and EndoC-{beta}H5 cells, showing similar functional and transcriptomic changes.

This study investigates the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells, finding CaMK2-dependent insulinotropic effects but limited cytoprotection and transcriptomic modulation.

This paper challenges the dogma that beta-cell death in T1D is primarily apoptotic by presenting evidence for pyroptosis as a key mechanism driving islet inflammation and beta-cell demise.

The paper identifies 51 differentially regulated genes in UC colon and blood by comparing a DSS-UC mouse model with human UC data, suggesting biomarkers and therapeutic targets.