Cristina Zibetti

The paper introduces scCoGAPS and projectR to decompose cell identity into shared and species-specific factors, enabling transfer learning across datasets and species.

This study identifies global decreases in chromatin accessibility in AMD patients, linking epigenetic changes to disease progression and suggesting HDAC11 as a potential therapeutic target.

The paper shows that Lhx2, with its coactivator Ldb1 and corepressor Rnf12, regulates the balance between neurogenesis and gliogenesis in the retina by controlling cell cycle exit, Notch signaling, and expression of neurogenic factors.

This study identifies Lhx2 as a key regulator of chromatin accessibility and transcription factor binding in retinal progenitor cells, showing its role in stage-specific gene regulation.