Mechanistic insights into the color transformation of a non-FRET substrate for RNase activity detection
Sohyun Kim, Soonwoo Hong, Jada N. Walker, Yujie He, Anh-Thu Nguyen, Wei-Ru Chen, Saeed Seifi, Yuan-I Chen, Yu-An Kuo, Jennifer S. Brodbelt, Hsin‐Chih Yeh
This paper identifies the mechanism of color change in DNA/AgNC substrates upon nucleolytic cleavage and demonstrates their application in sensitive virus detection.
bioRxiv · Mar 13, 2026 · PreprintBioengineering