Author
The University of Texas at AustinORCID 0000-0002-7618-9052Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Anh-Thu Nguyen, Hieu Tran, Limin Chen, Abby Criswell, Susanna Bradbury, Yui Zhu, Yujie He, S H Kim, Yuan-I Chen, Trung Duc Nguyen, Soonwoo Hong, Yu-An Kuo, Saeed Seifi, Wei-Ru Chen, Stephanie K. Seidlits, , Hsin‐Chih Yeh
This paper introduces dHaloLife635, a chemigenetic fluorescence lifetime sensor for dopamine that shows selectivity and stability in live cells.
bioRxiv · Oct 30, 2026 · PreprintBioengineering
Yujie He, Zhenglin Yang, Yu-An Kuo, Yuting Wu, Diego Fonseca-Albert, Kyle K Le, Jeffrey Guo, Yanxing Wang, Anh-Thu Nguyen, Yuan‐I Chen, Sohyun Kim, Weiru Chen, Saeed Seifi, Soonwoo Hong, Trung Duc Nguyen, , Hsin‐Chih Yeh
This paper develops a high-throughput platform to rapidly adapt DNA aptamers against evolving SARS-CoV-2 variants, identifying mutants with improved binding affinity and specificity.
ACS Nano · Aug 14, 2026Peer-reviewedBioengineering
Yu-An Kuo, Y.-I. Chen, Naseem Siraj, Yujie He, Zhenglin Yang, Yanxing Wang, Emile J. Batchelder-Schwab, Zeynep Korkmaz, Siem Yonas, Trung D. Nguyen, Soonwoo Hong, Anh-Thu Nguyen, S H Kim, Saeed Seifi, Po‐Hsun Fan, , Hsin‐Chih Yeh
This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.
ACS Sensors · May 11, 2026Peer-reviewedBiophysics
Sohyun Kim, Soonwoo Hong, Jada N. Walker, Yujie He, Anh-Thu Nguyen, Wei-Ru Chen, Saeed Seifi, Yuan-I Chen, Yu-An Kuo, Jennifer S. Brodbelt, Hsin‐Chih Yeh
This paper identifies the mechanism of color change in DNA/AgNC substrates upon nucleolytic cleavage and demonstrates their application in sensitive virus detection.
bioRxiv · Mar 13, 2026 · PreprintBioengineering
Sijbren Kramer, Ryungeun Song, Yujia Huang, Soonwoo Hong, Ibrahim Motlani, Howard A. Stone, Cameron Myhrvold
This paper introduces a portable microfluidic device for highly multiplexed nucleic acid detection, demonstrating its integration with CRISPR-based technology for rapid pathogen and variant detection.
bioRxiv · Aug 11, 2025 · PreprintBioengineering