Hsin‐Chih Yeh

This paper introduces dHaloLife635, a chemigenetic fluorescence lifetime sensor for dopamine that shows selectivity and stability in live cells.

This paper develops a high-throughput platform to rapidly adapt DNA aptamers against evolving SARS-CoV-2 variants, identifying mutants with improved binding affinity and specificity.

This study shows that arterial-like flow alters fibrin structure, reduces molecular transport, and decreases binding of fibrinolytic enzymes like Plg and tPA.

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

This paper introduces a fluorescence-lifetime-based multiplexed detection strategy using fluorogenic aptamers to distinguish viral RNA targets with minimal cross-reactivity and spectral overlap.

This paper identifies the mechanism of color change in DNA/AgNC substrates upon nucleolytic cleavage and demonstrates their application in sensitive virus detection.

This study shows that a ketomimetic medium increases chemoresistance and invasiveness of breast cancer cells through hypersialylation and lipid synthesis pathways.

This paper introduces a deep learning model to analyze multiscale brain activity dynamics and demonstrates its effectiveness in capturing causal interactions across scales.

This paper introduces a model to infer brain communication across scales and shows it outperforms existing methods in accuracy and predictive power.