This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedNeuroscience

A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma

Anja Wessely, Christopher Lischer, Adrian Weich, Claudia Kammerbauer, Esther Güse, Elias A. T. Koch, Xin Lai, Jan Dörrie, Michael A. Erdmann, Caroline Voskens, Stefan Schliep, Jens H. L. Neumann, Markus Eckstein, Harald L. J. Knorr, Beatrice Schuler‐Thurner, , Markus Vincent Heppt

The paper identifies E2F transcription factors as potential druggable targets in uveal melanoma by analyzing SOX10's role and its downstream effects.

bioRxiv · Oct 14, 2025 · PreprintCancer Biology

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases

Christina Plattner, Gregor Sturm, Anja Andrea Kühl, Raja Narayana Atreya, Sandro Carollo, Dietmar Rieder, Raphael Gronauer, Michael Günther, Steffen Ormanns, Claudia Manzl, Stefan Wirtz, Asier Rabasco Meneghetti, Ahmed Nabil Hegazy, Jay V. Patankar, Zunamys Itzell Carrero, , Jakob Nikolas Kather

This study integrates multi-omic and multimodal data from IBD patients to identify molecular, histopathological, and clinical features associated with inflammatory bowel diseases.

Gastroenterology · Mar 27, 2025Peer-reviewedMolecular Biology