Dieter Chichung Lie

This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.

This study shows that SOX4/11 transcription factors are critical for mitotic fidelity in adult hippocampal precursor cells, with loss leading to mitotic defects and cell death.

The paper investigates how long-lived adult-born hippocampal neurons contribute to cognitive resilience in aging rats, showing their role in maintaining synaptic inputs and mitochondrial homeostasis.

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

The paper investigates how mutations in SOX11, MID1, and TCF4 affect neurite formation in neurodevelopmental disorders, revealing shared molecular and cellular mechanisms.

This study uses snRNA-seq to track the transcriptional changes in adult hippocampal neurons from birth to maturity, identifying key transcription factors and molecular switches involved in their differentiation.

The paper shows that mitochondrial fusion during a critical period supports synaptic plasticity and circuit integration in adult-born neurons.

This study shows Nr2f1 regulates mitochondrial dynamics in adult-born hippocampal neurons, linking it to BBSOAS pathogenesis.

The paper identifies a TCF-4-dependent transcription factor network regulating commissure development in mice using scRNA-seq and bioinformatic analysis.

This study shows that canonical Wnt/{beta}-catenin signaling modulates the timing and progression of dendritic growth in adult-born hippocampal neurons, with distinct effects in young and aged mice.