Steffen Ormanns

WNT-driven immune evasion promotes malignant transformation of BRAF-mutant colorectal cancer

This study shows that WNT signaling enables immune evasion in BRAF-mutant colorectal cancer, promoting tumor progression through changes in T cell phenotypes.

Ex Vivo Assay for Organ-Specific Cancer Cell Invasion

This paper develops an ex vivo model using organ-derived ECM scaffolds to study cancer cell invasion, showing organ-specific invasion patterns that match clinical observations.

Genotype-phenotype mapping identifies fetal-like CD55+ immunoregulatory cancer cells as mediators of immune escape in colorectal cancer

Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer

The paper integrates single-cell data from CRC patients to identify immune subtypes and neutrophil phenotypes, revealing their spatial organization and tumor-induced changes.

PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer.

This study identifies PCSK9 as a key determinant of metastatic organ preference in pancreatic cancer by regulating cholesterol acquisition and utilization in liver versus lung environments.

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases

This study integrates multi-omic and multimodal data from IBD patients to identify molecular, histopathological, and clinical features associated with inflammatory bowel diseases.