Britta Siegmund

Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases

This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.

Integrated multi-model analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD

The paper compares 13 mouse models of intestinal inflammation with human IBD datasets to identify translatable pathways and introduces a web tool for analyzing these models.

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases

This study integrates multi-omic and multimodal data from IBD patients to identify molecular, histopathological, and clinical features associated with inflammatory bowel diseases.

Mucosal washes are useful for sampling intestinal mucus-associated microbiota despite low biomass

The paper compares mucus-associated microbiota sampling methods in mice and humans, finding that mucosal washes yield less host contamination and comparable microbiota diversity to biopsies and scrapings.

Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients

The paper investigates SARS-CoV-2 entry into the CNS via the olfactory mucosa in COVID-19 patients and demonstrates neurotropism and cerebral thromboembolism.