Xosé R. Bustelo

This study identifies oncogenic drivers, expression signatures, and therapeutic vulnerabilities in RHO GTPase pathway genes across multiple cancer types using pan-cancer genomic and transcriptomic data.

The paper investigates the phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish, finding that microexon deletions have mild effects while Srrm3/4 loss causes severe neurodevelopmental and behavioral changes.