Le Sun

CellCUT improves spatial transcriptomics by accurately segmenting cells and assigning transcripts using nuclear images, outperforming existing methods in diverse tissues and challenging data conditions.

The paper identifies molecularly distinct neuronal subtypes in the superior colliculus that mediate predator avoidance and prey capture behaviors through separate transcriptomic codes.

This study creates a single-cell transcriptome atlas of human and macaque retinas across ages, revealing species-specific molecular features and age-related changes in cell types and disease associations.

This paper develops vascularized human cortical organoids that model cortical development and show synaptic activity and integration potential in vivo.

The paper develops FIST analysis to study light-sensitive neurons in mouse V1, finding specific gene expression patterns associated with light responsiveness.