Qian Wu

TransBrain translates brain-wide phenotypes between humans and mice, improving homology mapping and enabling cross-species analysis of brain organization and function.

The paper investigates the evolutionary transition in plant reproduction from archegonia to embryo sacs and pollen tubes using transcriptomic data from Ginkgo and related species.

This study examines DCX knockout ferrets to understand neurogenic mechanisms in cortical development and reveals phenotypes resembling human lissencephaly.

CellCUT improves spatial transcriptomics by accurately segmenting cells and assigning transcripts using nuclear images, outperforming existing methods in diverse tissues and challenging data conditions.

The paper identifies molecularly distinct neuronal subtypes in the superior colliculus that mediate predator avoidance and prey capture behaviors through separate transcriptomic codes.

The paper examines the longitudinal development of brain network dynamics during childhood and adolescence, linking changes to gene expression profiles and ion transport-related genes.

This study uses single-cell RNA sequencing to analyze immune responses in COVID-19 patients, identifying key immune cell changes and molecular pathways linked to disease severity.

This study creates a single-cell transcriptome atlas of human and macaque retinas across ages, revealing species-specific molecular features and age-related changes in cell types and disease associations.

This paper develops vascularized human cortical organoids that model cortical development and show synaptic activity and integration potential in vivo.

The paper develops FIST analysis to study light-sensitive neurons in mouse V1, finding specific gene expression patterns associated with light responsiveness.

This study uses scRNA-Seq to analyze human and mouse retinal development, identifying conserved and species-specific gene expression patterns and a novel role for ATOH7 in photoreceptor specification.

This study uses single-cell RNA-seq to analyze human fetal retinal development, revealing transcriptional programs and developmental trajectories of retinal cell types.