Xiaoqun Wang

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

TransBrain translates brain-wide phenotypes between humans and mice, improving homology mapping and enabling cross-species analysis of brain organization and function.

This study shows that ER fusogens like ATL2 are essential for maintaining membrane reservoirs in the brain, supporting synaptic function and preventing deafness.

This study examines DCX knockout ferrets to understand neurogenic mechanisms in cortical development and reveals phenotypes resembling human lissencephaly.

CellCUT improves spatial transcriptomics by accurately segmenting cells and assigning transcripts using nuclear images, outperforming existing methods in diverse tissues and challenging data conditions.

This study introduces CAR-engineered astrocytes to target Aβ oligomers in Alzheimer's disease, showing improved phagocytosis and reduced inflammation in mice.

This study identifies de novo variants in Chinese ASD trios, finding that ASD without DD/ID has fewer disruptive variants and novel risk genes not in existing databases.

The paper identifies molecularly distinct neuronal subtypes in the superior colliculus that mediate predator avoidance and prey capture behaviors through separate transcriptomic codes.

This study uses single-cell RNA sequencing to analyze immune responses in COVID-19 patients, identifying key immune cell changes and molecular pathways linked to disease severity.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.

This study creates a single-cell transcriptome atlas of human and macaque retinas across ages, revealing species-specific molecular features and age-related changes in cell types and disease associations.

This paper develops vascularized human cortical organoids that model cortical development and show synaptic activity and integration potential in vivo.

The paper develops FIST analysis to study light-sensitive neurons in mouse V1, finding specific gene expression patterns associated with light responsiveness.

The paper identifies MRGPRX4 as a novel bile acid receptor involved in cholestatic itch, showing its activation by bile acids and its role in itch induction in humans.

This study identifies CNTNAP3 mutations in ASD cohorts and shows its role in synaptic development and social behavior in mice.

This study uses scRNA-Seq to analyze human and mouse retinal development, identifying conserved and species-specific gene expression patterns and a novel role for ATOH7 in photoreceptor specification.

This study uses single-cell RNA-seq to analyze human fetal retinal development, revealing transcriptional programs and developmental trajectories of retinal cell types.