Jaehyeon Jeong

The paper identifies a functional regulatory circuit involving TOP2B, BARD1, and ERK2 in IEG transcription, showing how their interactions are modulated by ubiquitination and phosphorylation.

This study identifies a novel DNA endonuclease activity of human ERK1, showing it can catalyze single-strand DNA breaks in a sequence-unspecific but topology-sensitive manner.

This study identifies ERK2's role in regulating TOP2B phosphorylation to facilitate transcriptional activation of immediate early genes.

This study shows that Lactiplantibacillus plantarum K8 lysates suppress hypoxia-induced gene expression by reducing HIF1 accumulation and its target genes.

This paper identifies a novel role for the BRCA1-BARD1 complex in regulating transcription by modulating topoisomerase IIβ stability and activity during gene activation.