Author

Alexander A. Lekan

Georgetown University Medical CenterORCID 0000-0001-9410-3067Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Anju DuttargiiD· 1 shared Annabel J LeeiD· 1 shared Atul M. DeshpandeiD· 1 shared Brent T. HarrisiD· 1 shared Elana Judith FertigiD· 1 shared Ivana PeraniD· 1 shared Louis M. WeineriD· 1 shared Lucia WetherilliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anju DuttargiORCID

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1 paper

Recent·Most cited

Cancer BiologyCancer Immunology ResearchPeer-reviewedJul 24, 2026

Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer

Zoe X. Malchiodi, Alexander A. Lekan, Robert K. Suter…·Louis M. Weiner

The paper identifies periductal fibroblast density as a key factor in immune exclusion in pancreatic cancer, showing that CD44-dependent stromal checkpoints restrict leukocyte access to tumor epithelium.

9 citationstop 1%

humanspatial transcriptomics

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