Robert K. Suter

Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer

The paper identifies periductal fibroblast density as a key factor in immune exclusion in pancreatic cancer, showing that CD44-dependent stromal checkpoints restrict leukocyte access to tumor epithelium.

Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

The paper integrates single-cell RNA sequencing data with drug response signatures to identify drug-sensitive and resistant glioblastoma cell states and predict synergistic drug combinations.

In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients

This paper develops DrugSeq, a computational platform that predicts drug sensitivities in medulloblastoma subgroups, identifying subgroup-specific therapies and potential drug repositioning candidates.

Multiple distinct metastatic cell states are induced by epithelial-mesenchymal plasticity

This study identifies multiple metastatic cell states in TNBC through EMT plasticity, showing that metastatic competence arises from diverse EMT programs rather than a single phenotype.

OrthologAL: A Shiny application for quality-aware humanization of non-human pre-clinical high-dimensional gene expression data

OrthologAL converts non-human transcriptomics data to human orthologs for drug discovery, preserving data structure and enabling use with human-annotated databases.

Identification of disease-specific vulnerability states at the single-cell level

The paper identifies three single-cell vulnerability states in glioblastoma using transcriptomic data and CRISPR screens, showing differential drug sensitivity and spatial distribution.