Cell BiologybioRxivPreprint
Glucagon-like peptide-1 receptor C-terminal tail phosphorylation determines signalling responses from pancreatic β-cells
Yusman Manchanda, Natalie Sean Man Wong, Annabelle J. Milner, Alejandra Tomás
This study shows that phosphorylation of specific C-terminal serine doublets in the GLP-1R is critical for receptor signaling in β-cells, with basal phosphorylation influencing receptor dynamics and signaling outcomes.
DOI 10.1101/2025.11.01.686001