Yusman Manchanda

In vivo functional profiling and structural characterisation of the human Glp1r A316T variant

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

Human class B1 GPCR modulation by plasma membrane lipids

The paper uses molecular dynamics simulations and FRET assays to study lipid interactions with class B1 GPCRs, revealing state-dependent and conserved lipid binding patterns.

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.

Glucagon-like peptide-1 receptor C-terminal tail phosphorylation determines signalling responses from pancreatic β-cells

This study shows that phosphorylation of specific C-terminal serine doublets in the GLP-1R is critical for receptor signaling in β-cells, with basal phosphorylation influencing receptor dynamics and signaling outcomes.

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

This paper describes the synthesis and properties of a novel dual GLP-1R/GIPR agonist, HISHS-2001, showing improved pharmacological profile compared to tirzepatide in vitro and in vivo.

The physiological impact of an N-terminal Halo-tag on GIPR function in mice

This study evaluates the impact of an N-terminal Halo-tag on GIPR function in mice, finding reduced cAMP responses and impaired glucose tolerance in tagged mice.