Hyongsok Tom Soh

The paper shows that charge-screening, not structure switching, is the main signal transduction mechanism in aminoglycoside electrochemical aptamer sensors.

This paper identifies high-performance split sites in DNA aptamers through large-scale mutational analysis, improving signal-to-background ratio for RNA detection.

This paper introduces ASWIFT, a tool for automated SWV signal quantification that outperforms existing methods in simulated and in vivo settings.

This paper develops a charge-amplified FET biosensor for detecting small-molecule biomarkers with picomolar sensitivity in complex biological samples.

This paper introduces a method to sequence peptides by converting them into DNA barcodes and demonstrates its ability to detect single amino acid substitutions and post-translational modifications.

The paper introduces A-PACE, an open-source toolkit for real-time electrochemical data analysis, improving peak detection, baseline fitting, and data processing efficiency.

This paper develops high-specificity DNA aptamers for progesterone using a high-throughput array platform, achieving nanomolar affinity and minimal cross-reactivity with structurally similar steroids.

This paper introduces MAPA, a high-throughput platform for discovering and optimizing aptamer beacons for molecular targets, demonstrating its effectiveness for glucose, serotonin, and dopamine.

This paper improves the efficiency of FACS sorting of double emulsion picoreactors by optimizing surfactants and using a 3D-printed vertical mixer, achieving high accuracy and recovery in sorting.

This paper develops an optical method to directly detect factor Xa activity in whole blood, enabling rapid anticoagulant monitoring and personalized treatment.

The paper introduces xPlex, a method for multiplexed and quantitative detection of small-molecule analytes using aptamer switches and UV-crosslinkable strands, demonstrating its effectiveness with dopamine and glucose.

This paper describes a method to isolate pH-sensitive aptamers through direct selection, demonstrating aptamers with switchable binding affinity at different pH levels.