David Jordan

This paper develops a heterologous expression system in yeast to rapidly test and discover resistance-conferring mutations from multiple pathogenic fungi.

The paper curates AMR mutations in fungi to create FungAMR, identifies universal resistance mutations, and provides a tool to screen genomes for AMR mutations.

The paper measures how mutations in residues near an SH3-binding motif affect binding strength in vivo and proposes a model involving interactions outside the canonical binding pocket.