Adnane Sellam

A new fungal taurine biosynthetic pathway promotes metabolic fitness and virulence in Candida albicans

This study identifies a novel fungal taurine biosynthetic pathway in Candida albicans, showing its role in metabolic fitness and virulence.

Isw2-mediated chromatin remodeling governs antifungal tolerance and heteroresistance in Candida albicans

This study identifies Isw2-mediated chromatin remodeling as a regulator of antifungal tolerance and heteroresistance in Candida albicans, revealing its role in suppressing CRZ1 transcription and modulating drug responses.

Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen Candida albicans

This study identifies Met32 as a master regulator of sulfur utilization and resistance to reactive sulfur species in C. albicans, highlighting its role in fungal virulence.

A structure-guided pipeline yields peptide inhibitors that disarm fungal peptidase-driven virulence and resistance

The paper designs peptide inhibitors targeting fungal peptidases to reduce virulence and resistance without harming host cells, showing efficacy in vitro and in vivo.

Crosstalk between the Ino80 complex and TOR signaling drives fungal adaptation to hypoxia through chromatin remodeling

This study identifies the TOR signaling pathway and Ino80 chromatin-remodeling complex as key regulators of hypoxic adaptation in Candida albicans by coordinating phosphate homeostasis and chromatin accessibility.

Manganese homeostasis modulates glucan and chitin unmasking in the opportunistic yeast Candida albicans

This study shows that manganese homeostasis in Candida albicans affects cell wall integrity and antigen exposure, altering immune recognition.

FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi

The paper curates AMR mutations in fungi to create FungAMR, identifies universal resistance mutations, and provides a tool to screen genomes for AMR mutations.

The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in C. albicans

This study identifies Adr1 as a transcription factor regulating ergosterol pathway and azole resistance in C. albicans, with functional interactions with Upc2.

High resolution genome-wide occupancy in Candida spp. using ChEC-seq

The paper introduces ChEC-seq, a PCR-based method for high-resolution genome-wide occupancy mapping of transcriptional regulators in Candida species, demonstrating its application on the SWI/SNF complex and NsiI.

Genome-wide screen for haploinsufficient cell size genes in the opportunistic yeast Candida albicans

The paper performs a genome-wide screen in Candida albicans to identify genes critical for cell size homeostasis, finding both conserved regulators and novel genes, some of which are linked to pathogenicity.