Author

Matthew Kyle Hadden

University of ConnecticutORCID 0000-0001-9482-1712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Andrew CromptoniD· 2 shared Dmitry M. KorzhneviD· 2 shared Naveen Kothandaraman· 2 shared Nimrat ChatterjeeiD· 2 shared Aarzoo Grover· 1 shared Ava SiegeliD· 1 shared Daniel AlmsteadiD· 1 shared Erica N. LamkiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andrew CromptonORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 30, 2026

Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells

Madison Guyette, Sombodhi Bhattacharya, Naveen Kothandaraman…·Nimrat Chatterjee

This study shows that targeting REV7 with C10 sensitizes colorectal cancer cells to microtubule disruption, revealing a mitotic vulnerability.

DOI 10.64898/2026.09.29.755408

humanexperimental assay

𝕏 PostBluesky

GeneticsOpen BiologyPeer-reviewedDec 1, 2025

REV1 inhibition enhances trinucleotide repeat mutagenesis

Ava Siegel, Daniel Almstead, Naveen Kothandaraman…·Nimrat Chatterjee

This study shows that inhibiting REV1, a TLS polymerase, increases trinucleotide repeat instability in human cells, suggesting REV1 protects against TNR mutagenesis.

2 citations

humanexperimental assay

𝕏 PostBluesky