REV1 inhibition enhances trinucleotide repeat mutagenesis
Ava Siegel, Daniel Almstead, Naveen Kothandaraman, Jessica Reich, Erica N. Lamkin, Joshua Victor, Aarzoo Grover, Kanayo Ikeh, Hannah Koval, Andrew Crompton, Hongjun Jang, Hyejin Lee, Roxana del Río, Dmitry M. Korzhnev, Matthew Kyle Hadden, , Nimrat Chatterjee
This study shows that inhibiting REV1, a TLS polymerase, increases trinucleotide repeat instability in human cells, suggesting REV1 protects against TNR mutagenesis.
Open Biology · Dec 1, 2025Peer-reviewedGenetics