Author

Cristina Bustos

Pontificia Universidad Católica de ValparaísoORCID 0000-0001-9503-2993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Julio BerríosiD· 2 shared Patrick FickersiD· 2 shared Rocio CozmariD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBioengineering

Julio BerríosORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintApr 1, 2025

Sorbitol uptake and oxygen transfer shape AOX1 promoter induction under methanol-free conditions in Komagataella phaffii lacking formate dehydrogenase

Cristina Bustos, Rocio Cozmar, Julio Berríos, Patrick Fickers

This study shows that increased sorbitol metabolism reduces AOX1 promoter induction in K. phaffii, while lower oxygen transfer enhances it, affecting recombinant protein productivity.

DOI 10.1101/2025.04.01.646572

yeastbulk RNA-seq

MicrobiologyMicrobial BiotechnologyPeer-reviewedOct 1, 2024

Formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficient Pichia pastoris

Cristina Bustos, Julio Berríos, Patrick Fickers

The paper shows that formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficient Pichia pastoris, enabling self-induced protein expression without methanol.

8 citations

yeastproteomics